4-hydroxyisoindole-1,3-dione synthesis

5synthesis methods

Product Name:4-hydroxyisoindole-1,3-dione
CAS Number:41709-87-9
Molecular formula:C8H5NO3
Molecular Weight:163.13

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Yield:41709-87-9 45%

Reaction Conditions:

with ammonium hydroxide

Steps:

R.25 REFERENTIAL EXAMPLE 25

REFERENTIAL EXAMPLE 25 Production of 3-hydroxyphthalimide: 3.64 g (0.02 mole) of 3-hydroxyphthalic acid and 5.61 g (0.04 mole) of 25% aqueous ammonia were charged into a 50 ml SUS 314 stainless steel autoclave, and reacted with stirring at 190° C. for 6 hours. The reaction mixture was gradually cooled to room temperature, and then adjusted to pH 2 with concentrated hydrochloric acid. The crystals which precipitated were collected by suction-filtration and then dried in vacuum to give 1.45 g (yield 45%) of the desired compound. ¹ H-NMR spectrum (CDCl₃, δpm):

References:

US5192799,1993,A