4-(HydroxyMethyl)thiophene-2-carboxylic acid synthesis

Yield: 95%

Reaction Conditions:

with sodium hydroxide in methanol;water at 20; for 1 h;

Steps:

6-24.12.3
This compound (60 mg, 0.348 mmol) was dissolved in methanol (1 ml) at room temperature. 1N NAOH aqueous solution (1 ml) was slowly added therein, and the reaction mixture was stirred at room temperature for 1 hour, to give 50 mg (yield: 95%, white solid) of the target compound.

References:

JE IL PHARMACEUTICAL CO., LTD. WO2004/113281, 2004, A1 Location in patent:Page 75