4-Imidazolidinecarboxylicacid,2-oxo-,(4R)-(9CI) synthesis

Yield:214767-15-4 565 mg

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in tetrahydrofuran;methanol at 20; under 760.051 Torr; for 24 h;

Steps:

20.2 (2) (R)-2-Oxoimidazolidine-4-carboxylic Acid

Under nitrogen atmosphere, to a solution of (R)-2-oxoimidazolidine-1,5-dicarboxylic acid 1-benzyl ester (1.61 g) in methanol/tetrahydrofuran (4/1, 20 ml) was added 10 wt % palladium on carbon (161 mg) at room temperature, and the mixture was stirred for 24 hours under one atmosphere of hydrogen.
Under nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite, and the filtrate was concentrated under reduced pressure.
To the resulting residue were added diisopropyl ether and n-hexane, and the mixture was stirred.
A solid was collected from this suspension by filtration, and dried under reduced pressure to give the titled compound (565 mg).

References:

US2013/85132,2013,A1 Location in patent:Page/Page column 0916; 0920; 0921;