4-M-TOLYL-THIAZOL-2-YLAMINE synthesis

5synthesis methods

Product Name:4-M-TOLYL-THIAZOL-2-YLAMINE
CAS Number:5330-67-6
Molecular formula:C10H10N2S
Molecular Weight:190.26

72927-80-1 Synthesis

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5330-67-6
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Yield:5330-67-6 95%

Reaction Conditions:

with iodine in dimethyl sulfoxide at 80; for 0.0166667 h;Green chemistry;

Steps:

General procedure for the catalytic synthesis of 2-aminothiazoles

General procedure: A mixture of methylcarbonyl (1 mmol), thiourea (1.5 mmol), I2(1 mmol) and Nizeolite-Im-IL (15 mg) in DMSO (2 mL) was stirred at 80 °C for desired time. Afterthe satisfactory completion of the reaction (monitored by TLC), the nanocatalystwas separated through centrifugation. The reaction media (DMSO) was quenchedby adding ammonia to pH = 9-10 to give the solid products. Finally, the pure productwas recrystallized from ethanol at a high yield. All 2-aminothiazole products areknown and were identified by comparing their melting point, FT-IR and 1H NMRwith authentic samples.

References:

Kalhor, Mehdi;Zarnegar, Zohre [Research on Chemical Intermediates,2022,vol. 48,# 2,p. 519 - 540]

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585-74-0 Synthesis