4-METHYL-1H-IMIDAZOLE-2-CARBOXYLICACID synthesis
- Product Name:4-METHYL-1H-IMIDAZOLE-2-CARBOXYLICACID
- CAS Number:70631-93-5
- Molecular formula:C5H6N2O2
- Molecular Weight:126.11
40253-44-9
70631-93-5
General procedure for the synthesis of 4-methyl-1H-imidazole-2-carboxylic acid from ethyl 4-methyl-1H-imidazole-2-carboxylate: ethyl 4-methyl-1H-imidazole-2-carboxylate (77.0 g, 0.5 mol) was dissolved in anhydrous ethanol (600 mL) at room temperature, and 250 mL of 40% aqueous sodium hydroxide was subsequently added. The reaction mixture was heated to 50 °C and maintained at this temperature for the reaction. Upon completion of the reaction, it was cooled to room temperature, neutralized and acidified with 37% concentrated hydrochloric acid to pH=6. The solvent was removed by distillation under reduced pressure and the resulting residue was purified by column chromatography using dichloromethane/methanol (10:1, v/v) as eluent to give the final 4-methyl-1H-imidazole-2-carboxylic acid (60.2 g, 96% yield) as a white solid.
40253-44-9
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70631-93-5
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Yield: 96%
Reaction Conditions:
with water;sodium hydroxide in ethanol at 20 - 50; for 1 h;
Steps:
1.4 Preparation of 4-methyl -1H- imidazole-2-carboxylic acid (4)
At room temperature, a solution of 4-methyl -1H- imidazole-2-carboxylate (3, 77.0g, 0.5mol) in absolute ethanol (600mL) was added 250mL of aqueous sodium hydroxide (40%).The reaction was heated to 50oC and maintained 1h.Cooled to room temperature, neutralized with concentrated hydrochloric acid (37%) was acidified to pH = 6.The solvent was removed under reduced pressure, the residue was purified by column chromatography (methylene chloride / methanol = 10/1 as eluent) to give the title compound4(60.2g, 96%), as a white solid.
References:
ZUNYI MEDICAL UNIVERSITY;WANG, XIANHENG;ZHAO, CHANGKUO CN104016925, 2016, B Location in patent:Paragraph 0028-0030; 0038; 0039
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1000210-73-0
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70631-93-5
76 suppliers
$81.00/250mg