4-METHYLHEXANOIC ACID synthesis
- Product Name:4-METHYLHEXANOIC ACID
- CAS Number:1561-11-1
- Molecular formula:C7H14O2
- Molecular Weight:130.19
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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Yield: 432 mg
Reaction Conditions:
at 210; for 2 h;Inert atmosphere;
Steps:
Afterward, a mixture of dimethyl 2-(2-methylbutyl)malonate (3.7 mmol), an aqueous solution of NaOH (15 mmol in 40 mL), and EtOH (10 mL) was stirred and refluxed for 4 hours. EtOH was evaporated, the water layer was washed with Et2O (2 × 50 mL), then acidified with 1 M HCl and extracted with Et2O (5 × 50 mL). Combined ether extracts were concentrated under reduced pressure to yield crude 2-(2-methylbutyl)malonic acid (616 mg) that was subsequently decarboxylated by heating at 210 °C for 2 hours under nitrogen. The obtained dark oil was purified by dry-flash chromatography on SiO2 using mixtures of the increasing polarity of hexane and EtOAc as the eluent to give pure 4-methylhexanoic acid (432 mg).
References:
Đorđević, Miljana R.;Živković Stošić, Milena Z.;Aksić, Jelena M.;Genčić, Marija S.;Mladenović, Marko Z.;Radulović, Niko S. [Natural Product Research,2020] Location in patent:supporting information
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1561-11-1
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![Spiro[2,4-benzodioxepin-3,1'-cyclopropane]-2'-methanol, α-ethyl-1,5-dihydro-α-methyl-](/CAS/20210305/GIF/100340-02-1.gif)
100340-02-1
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1561-11-1
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1000210-73-0
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1561-11-1
50 suppliers
$24.00/100mg