4-(Methylsulfonyl)phenol synthesis
- Product Name:4-(Methylsulfonyl)phenol
- CAS Number:14763-60-1
- Molecular formula:C7H8O3S
- Molecular Weight:172.2
1073-72-9
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$6.00/1g
14763-60-1
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$11.00/5g
Yield:14763-60-1 96%
Reaction Conditions:
with Oxone in ethanol;water at 20; for 18 h;
Steps:
75.2 Step 2. 4-(methylsulfonyl)phenol
Step 2. 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) (Aldrich cat22803-6) was added in portions to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL) and water (10.0 mL) at room temperature. The reaction mixture was stirred for 18 h then partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated in vacuo to afford 4-(methylsulfonyl)phenol as a semisolid (0.60 g, 96%). LCMS calculated for C7H9O3S (M+H)+: m/z = 173.0; found: 173.0.
References:
WO2015/164480,2015,A1 Location in patent:Page/Page column 106; 107
3466-32-8
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$8.00/1g
14763-60-1
164 suppliers
$11.00/5g
1073-72-9
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$6.00/1g
14763-64-5
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$45.00/10mg
14763-60-1
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$11.00/5g
455-15-2
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$12.00/1g
14763-60-1
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98-57-7
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$24.00/10g
14763-60-1
164 suppliers
$11.00/5g