4-(Methylsulphonyl)benzene-1,2-diamine synthesis

7synthesis methods

Product Name:4-(Methylsulphonyl)benzene-1,2-diamine
CAS Number:21731-57-7
Molecular formula:C7H10N2O2S
Molecular Weight:186.23

Benzenamine, 5-(methylsulfonyl)-2-nitro-

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21731-57-7
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Yield:21731-57-7 90%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 2 h;

Steps:

33.2 4-methanesulfonylbenzene-1,2-diamine

The compound 5-methanesulfonyl-2-nitroaniline 33b (0.65 g, 3 mmol), 10% palladium carbon (20 mg) and methanol (50 ml) were mixed, and then stirred at room temperature under a hydrogen atmosphere for 2 hours. The palladium carbon was removed by filtration, and the filtrate was removed under reduced pressure. To give the desired product 4-methanesulfonyl-1,2-diamine 33c (0.5g, white solid), yield: 90%.

References:

CN109956927,2019,A Location in patent:Paragraph 0352; 0354-0355