4-Nitro-1H-indole-2- carboxylic acid synthesis
- Product Name:4-Nitro-1H-indole-2- carboxylic acid
- CAS Number:16732-60-8
- Molecular formula:C9H6N2O4
- Molecular Weight:206.15
16792-45-3
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4993-93-5
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$214.00/250mg
16732-60-8
20 suppliers
$166.00/250mg
10242-00-9
74 suppliers
$45.00/50mg
Yield:-
Reaction Conditions:
Stage #1:6-nitro-1H-indole-2-carboxylic acid ethyl ester;4-nitro-1H-indole-2-carboxylic acid ethyl ester with sodium hydroxide;waterHeating / reflux;
Stage #2: with hydrogenchloride in water; pH=1 - 2 at 20;
Steps:
49
A mixture of ethyl 6-nitro-1H-indole-2-carboxylate (0.5 g) and 10% NaOH (20 mL) was heated at reflux overnight and then was cooled to room temperature. The mixture was extracted with ether and the aqueous phase was acidified with HCl to pH 1-2. The insoluble solid was isolated by filtration to give a crude mixture that was taken on to the next step without purification (0.3 g, 68%).
References:
Hadida Ruah, Sara S.;Grootenhuis, Peter D.J.;Van Goor, Frederick;Zhou, Jinglan;Bear, Brian;Miller, Mark T.;McCartney, Jason;Numa, Mehdi Michel Jamel US2007/244159, 2007, A1 Location in patent:Page/Page column 139
134747-25-4
4 suppliers
$55.10/250mg
16732-60-8
20 suppliers
$166.00/250mg
10242-00-9
74 suppliers
$45.00/50mg
1056933-72-2
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16732-60-8
20 suppliers
$166.00/250mg
10242-00-9
74 suppliers
$45.00/50mg
4993-93-5
45 suppliers
$214.00/250mg
16732-60-8
20 suppliers
$166.00/250mg
134747-25-4
4 suppliers
$55.10/250mg
16732-60-8
20 suppliers
$166.00/250mg