4-PHENOXYPHENYLACETIC ACID synthesis
- Product Name:4-PHENOXYPHENYLACETIC ACID
- CAS Number:6328-74-1
- Molecular formula:C14H12O3
- Molecular Weight:228.24
4664-61-3
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6328-74-1
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$20.00/250mg
Yield: 91%
Reaction Conditions:
Stage #1:methyl [p-(phenoxy)phenyl]acetate with sodium hydroxide;water in ethanol at 20; for 5 h;
Stage #2: with hydrogenchloride in water
Steps:
B183.2
1 N-NaOH aqueous solution (7.8 mL) was added to an ethanol (20 mL) solution of methyl 4-phenoxyphenylacetate (948 mg, 3.9 mmol), and stirred for 5 hours at room temperature. The reaction solution was concentrated under reduced pressure, and 1 N hydrochloric acid aqueous solution (10 mL) was added. The precipitated white solid was filtered out and washed successively with water and ether to obtain 4-phenoxyphenylacetic acid (813 mg, 91%) as a white solid. LC-MS 229 [M+H]+ 1H-NMR (300MHz, CDCl3); δ 6.92-7.01 (m, 4H), 7.10-7.14 (t, J=6.6Hz, 1H), 7.25-7.28 (d, J=8.4Hz, 2H), 7.35-7.41 (m, 2H)
References:
Takeda Pharmaceutical Company Limited EP1849465, 2007, A1 Location in patent:Page/Page column 139
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1000210-73-0
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6328-74-1
102 suppliers
$20.00/250mg
1000210-73-0
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1000210-73-0
0 suppliers
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6328-74-1
102 suppliers
$20.00/250mg
1000210-73-0
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6328-74-1
102 suppliers
$20.00/250mg
92163-15-0
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$32.00/500 mg
6328-74-1
102 suppliers
$20.00/250mg