(4-phenyl-1,3-thiazol-2-yl)methanol synthesis
- Product Name:(4-phenyl-1,3-thiazol-2-yl)methanol
- CAS Number:65384-99-8
- Molecular formula:C10H9NOS
- Molecular Weight:191.25
110704-59-1
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65384-99-8
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Yield:65384-99-8 87%
Reaction Conditions:
with potassium hydroxide in ethanol at 20; for 1 h;Cooling with ice;
Steps:
47 EXAMPLE 47 (4-Phenylthiazol-2-yl)methanol
Potassium hydroxide (1.06 g, 18.84 mmol) was added to an ice cooled solution of benzoic acid (4-phenylthiazol-2-yl)methyl benzoate (3.71 g, 12.56 mmol) in EtOH (40 mL).
The reaction mixture was slowly warmed to room temperature and allowed to stir for 1 h.
The reaction mixture was concentrated under reduced pressure and then diluted with water.
The organic product was extracted with EtOAc, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.
The crude product was purified by column chromatography (silica 60-120 mesh, eluant 10% EtOAc in petroleum ether) to get the pure (4-phenylthiazol-2-yl)methanol (2.1 g, yield 87%).
1H NMR (400 MHz, CDCl3) δ 7.89 - 7.87 (m, 2H), 7.46 - 7.41 (m, 3H), 7.37 - 7.33 (m, 1 H), 5.01 (s, 2H). MS (ESI) m/z: Calculated for C10H9NOS: 191.04; found: 192.2 (M+H)+.
References:
EP2533783,2015,B1 Location in patent:Paragraph 0459-0460
31877-30-2
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65384-99-8
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75390-44-2
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65384-99-8
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40235-62-9
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70-11-1
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65384-99-8
26 suppliers
$75.00/100mg
70-11-1
299 suppliers
$10.00/25g
65384-99-8
26 suppliers
$75.00/100mg