4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis
- Product Name:4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL
- CAS Number:93378-56-4
- Molecular formula:C15H13N3S
- Molecular Weight:267.35
103556-07-6
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93378-56-4
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Yield:93378-56-4 81%
Reaction Conditions:
with sodium hydroxide in water;Reflux;
Steps:
4.5.2. General procedure for the synthesis of 5-substituted-4-phenyl-4H-1,2,4-triazole-3-thiol (3f-3l)
General procedure: Various substituted carboxylic acid hydrazides (25.0 mmol) andphenyl isothiocyanate (25.0 mmol) were dissolved in toluene (30 ml).The reaction mixture was heated for 1-2 h. After completion of thereaction, toluene was evaporated using a rotary evaporator. The resultingprecipitates were filtered, washed with water, and recrystallizedfrom ethanol. Recrystallized thiosemicarbazides 7 was further refluxedwith 4 N sodium hydroxide for 4-5 h. After completion of cyclization,reaction mixture was acidified with dilute hydrochloric acid (adjustedpH 5-6). The resulting precipitates of 1,2,4-triazole-3-thiols 3f-3l werecollected through filtration, washed with water and recrystallized fromethanol.
References:
Shahzad, Sohail Anjum;Yar, Muhammad;Khan, Zulfiqar Ali;Shahzadi, Lubna;Naqvi, Syed Ali Raza;Mahmood, Adeem;Ullah, Sami;Shaikh, Ahson Jabbar;Sherazi, Tauqir Ali;Bale, Adebayo Tajudeen;Kuku?owicz, J?drzej;Bajda, Marek [Bioorganic Chemistry,2019,vol. 85,p. 209 - 220]
5351-69-9
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93378-56-4
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104-87-0
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93378-56-4
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103-72-0
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3619-22-5
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93378-56-4
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43002-64-8
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93378-56-4
17 suppliers
$147.00/100mg