4-(Phenylthio)Benzoic Acid synthesis
- Product Name:4-(Phenylthio)Benzoic Acid
- CAS Number:6310-24-3
- Molecular formula:C13H10O2S
- Molecular Weight:230.28
40730-41-4
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6310-24-3
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Yield:6310-24-3 96%
Reaction Conditions:
with lithium hydroxide monohydrate;water in tetrahydrofuran;methanol at 20; for 4 h;
Steps:
25.2 4-(phenylthio)benzoic acid.
4-(phenylthio)benzoic acid. A mixture of methyl 4-(phenylthio)benzoate (5 g, 20.4 mmol), lithium hydroxide monohydrate (1.1 g, 26 mmol), tetrahydrofuran (5 mL), methanol (1 mL) and water (1 mL) was stirred at 20°C for 4 hours. The mixture was neutralized to pH=l with concentrated hydrochloric acid and then extracted with ethyl acetate (15 mL x 3). The combined organic phase was dried by sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 4-(phenylthio)benzoic acid as a white solid(4.5 g, 96%). LRMS (M + H+) m/z: calcd 230.04; found 230.
References:
WO2013/75083,2013,A1 Location in patent:Paragraph 00234; 00236
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6310-24-3
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619-58-9
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6310-24-3
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150-13-0
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![Ethanone, 2-chloro-1-[4-(phenylthio)phenyl]-](/CAS/20180528/GIF/13067-87-3.gif)
13067-87-3
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6310-24-3
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