4-Pyridinecarboxylicacid,3-methyl-,hydrazide(9CI) synthesis
- Product Name:4-Pyridinecarboxylicacid,3-methyl-,hydrazide(9CI)
- CAS Number:176178-87-3
- Molecular formula:C7H9N3O
- Molecular Weight:151.17
116985-92-3
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Yield:-
Reaction Conditions:
with hydrazine hydrate monohydrate
Steps:
Procedure for the synthesis of compound 26:
To a stirred solution of 26e (200 mg, 1 Eq, 1.32 mmol) in MeOH (5 ml), was added hydrazine hydrate (0.3 ml, 5 Eq, 6.62 mmol) at RT, and the mixture heated to 70°C for 16 h.
Reaction progress was monitored by TLC (EtOAc, Rf: 0.3).
After completion of reaction, the reaction mixture was concentrated under reduced pressure, compound was triturated with diethyl ether (20 ml), filtered and dried to afford Compound 26f as off white solid (160 mg, crude).
3-methylisonicotinohydrazide (26f). Purity=95.1%; MS (ES+) m/z 152.17[M+1]
References:
EP4050002,2022,A1
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