4-Thiazolecarboxylicacid,5-bromo-2-methyl-(9CI) synthesis
- Product Name:4-Thiazolecarboxylicacid,5-bromo-2-methyl-(9CI)
- CAS Number:899897-20-2
- Molecular formula:C5H4BrNO2S
- Molecular Weight:222.06
1047675-70-6
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Yield:899897-20-2 100%
Reaction Conditions:
with water;sodium hydroxide in ethanol at 20; for 2 h;
Steps:
110 Preparation 110: 5-bromo-2-methyl-1,3-thiazole-4-carboxylic acid
To a mixture of ethyl 5-bromo-2-methyl-1 ,3-thiazole-4-carboxylate (p68, 0.41 g, 1.64 mmol) in 3.3 ml_ of EtOH was added at RT an aqueous solution of NaOH (3.3 ml_, 6.56 mmol, 2M). The resulting mixture was stirred at RT for 2 hours. Aqueous NH4CI ss and 1 .3 ml_ of HCI 6N were added to the mixture and then was extracted with EtOAc (4x). The collected organic layers were dried over Na2S04, filtered, concentrated under vacuum to give 5-bromo-2-methyl-1 ,3-thiazole-4-carboxylic acid (p1 10, 367 mg y=quant). MS (mlz): 223.9 [MH]+
References:
WO2019/43407,2019,A1 Location in patent:Page/Page column 116-117
35272-15-2
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221558-28-7
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