3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID synthesis
- Product Name:3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID
- CAS Number:40101-51-7
- Molecular formula:C15H9NO4
- Molecular Weight:267.24
85-44-9
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40101-51-7
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Yield:40101-51-7 94.3%
Reaction Conditions:
with acetic acid at 100; for 3 h;
Steps:
18 Example 18
Add phthalic anhydride (450 mg, 3.0 mmol) and 3-aminobenzoic acid (415 mg, 3.0 mmol) to glacial acetic acid(10 mL), heated to 100 ° C for 3 h. The reaction was quenched with water (10 mL).The pH of the solution was adjusted to 6-8 by a NaOH solution (0.1 mol/L). Dichloromethane extraction (10mL × 3),Wash with saturated NaHCO3 solution, wash with water, and combine with organicAfter drying, 746 mg of a yellow solid was obtained.LC-MS and 1 H-NMR confirmed the expected intermediate compound in a yield of 94.3%.
References:
CN109867661,2019,A Location in patent:Paragraph 0216; 0218
300667-12-3
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40101-51-7
44 suppliers
$100.00/100mg
99-05-8
542 suppliers
$14.00/5g
88-99-3
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40101-51-7
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$100.00/100mg
4518-10-9
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85-44-9
779 suppliers
$9.00/5g
40101-51-7
44 suppliers
$100.00/100mg
![Benzoic acid, 3-[(phenylmethylene)amino]-](/CAS/20210305/GIF/22774-11-4.gif)