ChemicalBook CAS DataBase List 3-Cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole

3-Cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole synthesis

4synthesis methods

Product Name:3-Cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole
CAS Number:40371-99-1
Molecular formula:C14H16N4O7
Molecular Weight:352.3

40372-03-0 Synthesis

40372-03-0
9 suppliers
inquiry

3-Cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole

40371-99-1
7 suppliers
inquiry

Yield:40371-99-1 87%

Reaction Conditions:

with triethylamine;trichlorophosphate in chloroform at 0 - 20; for 17 h;Concentration;

Steps:

1D Synthesis of 3-cyano-2’,3’,5’-O-triacetyl-3-D-ribo- furanosyl)-1,2,4-triazole 9

Synthesis of 3-cyano-2',3',5'-O-triacetyl-β-D-ribofuranosyl)-1,2,4-triazole 9 A mixture of crude 2’,3’,5’-O-triacetyl-fi-D-ribofurano- syl)-1,2,4-triazole-3-carboxamide (compound 8) (934 mg) and triethylamine (5.5 mE) in chloroform (10 mE) was cooled to 0° C. in an ice-water bath. Phosphorus oxychloride (0.7 mE, 7.57 mmol) was added dropwise with stirring and the solution was allowed to warm to room temperature. Afier the mixture was stirred at room temperature for 17 hours, the brown reaction mixture was concentrated to dryness in vacuum and the residue was dissolved in dichloromethane (20 mE). The organic solution was washed with saturated aqueous sodium bicarbonate (3x60 mE), dried over sodium sulfate, and concentrated. The residue was purified by columnchromatography on silica gel using MeOH/DCM (2%) toafford the product (0.7 18 g, 87% yield based on ribavirin).

References:

US9149538,2015,B2 Location in patent:Page/Page column 36; 37