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ChemicalBook CAS DataBase List [1,1'-Biphenyl]-4,4'-dicarboxylic acid, 2,2'-dihydroxy-
41738-72-1

[1,1'-Biphenyl]-4,4'-dicarboxylic acid, 2,2'-dihydroxy- synthesis

7synthesis methods
[1,1'-Biphenyl]-4,4'-dicarboxylic acid, 2,2'-dihydroxy-, 4,4'-dimethyl ester

109977-12-0
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Yield:41738-72-1 98%

Reaction Conditions:

Stage #1: dimethyl 2,2’-dihydroxy-1,1’-biphenyl-4,4’-dicarboxylatewith sodium hydroxide in tetrahydrofuran;methanol;water at 20;
Stage #2: with hydrogenchloride in water at 0; pH=1;

References:

Keene, Tony D.;Rankine, Damien;Evans, Jack D.;Southon, Peter D.;Kepert, Cameron J.;Aitken, Jade B.;Sumby, Christopher J.;Doonan, Christian J. [Dalton Transactions,2013,vol. 42,# 22,p. 7871 - 7879] Location in patent:supporting information