1-TERT-BUTYLOXYCARBONYL-3-(N-HYDROXYCARBAMIMIDOYL)PIPERIDINE synthesis

Yield:479080-28-9 100%

Reaction Conditions:

with hydroxylamine in ethanol;water; for 2 h;Reflux;

Steps:

3.C 3(C)

3(C) 3-(N-Hydroxycarbamimidoyl)-piperidine-1-carboxylic acid tert-butyl ester A solution of 3-cyano-piperidine-1-carboxylic acid tert-butyl ester (1.4 g, 6.89 mmol) and aqueous hydroxylamine (50% in water, 1.7 mL, 27.5 mmol) in ethanol (15 mL) was refluxed for 2 h. The solvent was evaporated under reduced pressure to afford the title compound that was used for the next step without further purification. Yield: quantitative; LCMS (RT): 2.71 min (Method A); MS (ES+) gave m/z: 244.0.

References:

US2009/215822,2009,A1 Location in patent:Page/Page column 11