1-[2-(4-fluorophenyl)-2-oxoethyl]pyridin-1-ium-3-carboxamide bromide synthesis
1synthesis methods
- Product Name:1-[2-(4-fluorophenyl)-2-oxoethyl]pyridin-1-ium-3-carboxamide bromide
- CAS Number:495-44-3
- Molecular formula:C14H12BrFN2O2
- Molecular Weight:339.16
Yield:495-44-3 71%
Reaction Conditions:
in ethanol; for 0.166667 h;Microwave irradiation;Wavelength;Solvent;Temperature;
Steps:
MW synthesis (B)
General procedure: :Toasolutionofnicotinamide(0.244g,2mmol)in10mLofsolvent(abs. ethanol or acetone), substituted 2-bromoacetophenones (2 mmol) were added and the reaction mixture was irradiated at 440 W for a 10 min. The crystals were removed from the solution by ltration, washed with diethyl ether and acetone and recrystallized from methanol.
References:
Siber, Tamara;Bu?i?, Valentina;Zobund?ija, Dora;Roca, Sun?ica;Viki?-Topi?, Dra?en;Vrande?i?, Karolina;Ga?o-Soka?, Dajana [Molecules,2019,vol. 24,# 6,art. no. 1001]