5-(1-hydroxyethyl)-1,3-thiazole-2-carbaldehyde synthesis

Yield:1080060-62-3 42%

Reaction Conditions:

with water;toluene-4-sulfonic acid in acetonitrile; for 9 h;Reflux;

Steps:

5-(1-Hydroxyethyl)-1,3-thiazole-2-carboxaldehyde (VIIIa).

0.0006 mol of p-toluenesulfonic acid was added to a solution of 0.006 mol of compound VIIa in 10 mL of acetonitrile and 4 mL of water. The mixture was refluxed during 9 h. After cooling to 20°C, 20 mL of ethyl acetate was added. The organic layer was separated, the solvent was removed under reduced pressure, and the residue was purified by chromatography (CH2Cl2-EtOAc, 80 : 20).

References:

Sinenko;Slivchuk;Bal'On, Ya. G.;Brovarets [Russian Journal of General Chemistry,2015,vol. 85,# 8,p. 1855 - 1861][Zh. Obshch. Khim.,2015,vol. 85,# 8,p. 1298 - 1304,7]