5-(2-hydroxyethyl)furan-2(3H)-one synthesis
- Product Name:5-(2-hydroxyethyl)furan-2(3H)-one
- CAS Number:878007-08-0
- Molecular formula:C6H8O3
- Molecular Weight:128.13
1196873-49-0
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878007-08-0
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Yield:878007-08-0 24%
Reaction Conditions:
with peracetic acid;sodium acetate in dichloromethane;water at 20; for 2 h;
Steps:
B.1.38
To a solution of the above compound (3g, 16.45 mmol) and NaOAc (1.64g, 20 mmol) in CH2CI2 (30mL) was added dropwise a solution of CH3C03H (16g, 40% in H20) in CH2CI2 (90mL). The reaction mixture was stirred for overnight at room temperature. The reaction was quenched with Na2S03, washed with saturated NaHC03 and brine. The organic layer was concentrated under reduced pressure. The resulting residue was purified by column chromatography (PE:EA=1 : 2) to give 0.5g of desired product as a yellow liquid (0.5g, yield: 24%).
References:
WO2011/107608,2011,A1 Location in patent:Page/Page column 81
887586-71-2
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878007-08-0
11 suppliers
inquiry