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5-(3,4-dimethoxyphenyl)pentanoic acid synthesis

11synthesis methods
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Yield:1145-15-9 96%

Reaction Conditions:

Stage #1: malonic acid;3-(3,4-Dimethoxyphenyl)propanalwith piperidine;pyridineReflux;Knoevenagel-Doebner-Stobbe Reaction;
Stage #2: with palladium 10% on activated carbon;hydrogen in ethyl acetate at 20; under 760.051 Torr;

References:

Ho, Sheau Ling;Lin, Ching-Ting;Lee, Shoei-Sheng [Drug Development Research,2021,vol. 82,# 6,p. 789 - 801]

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