[5-(4-fluorophenyl)-1,3-oxazol-2-yl]methanol synthesis

Yield:844818-52-6 79%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 20; for 2 h;

Steps:

B.2

NaBH4 (138 mg, 3.6 mmol) was added to a solution of 5-(4-fluorophenyl)-1, 3- OXAZOLE-2-CARBALDEHYDE (0.58 g, 3.03 mmol) in methanol (10 ml). The mixture was stirred at room temperature for 2 hours, then poured into water (50 ml), extracted with DCM (30 ml), washed with brine (20 ml), dried over MgS04 and concentrated in vacuo to afford 460 mg (79%) of the title compound: AL4 (360 MHz, CDC13) 2.57 (1H, M), 4.79 (2H, d, J5. 5) 7. 12 (2H, t, J8. 5), 7.24 (1H, s), 7. 60-7. 64 (2H, M) ; M/Z (ES+) 194 (MH+).

References:

WO2005/14553,2005,A1 Location in patent:Page/Page column 17