5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID synthesis
- Product Name:5-(4-METHYLPHENYL)-2-THIOPHENECARBOXYLIC ACID
- CAS Number:40808-21-7
- Molecular formula:C12H10O2S
- Molecular Weight:218.27
50971-49-8
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$112.00/5g
40808-21-7
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$65.00/100mg
Yield:40808-21-7 94%
Reaction Conditions:
with methanol;sodium hydroxide for 3 h;Reflux;
Steps:
9.2 Step 2:
Weigh 330 mg (1.42 mmol) of the intermediateMethyl 5- (4-methylphenyl) thiophene-2-carboxylate was added dropwise to 1 mL of 4 mol / L NaOH solution in 5 mL of methanol and refluxed for 3 h. The reaction was cooled to room temperature,Add water dissolved with 10% dilute hydrochloric acid to adjust the pH value to about 1,Extracted three times with ethyl acetate, the combined organic phases were washed twice with saturated brine and anhydrous sulfurSodium sulfate dried and evaporated to dry290 mg of intermediate 5- (4-methylphenyl) thiophene-2-carboxylic acid in 94% yield.
References:
CN103992311,2017,B Location in patent:Paragraph 0103; 0181
7311-63-9
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5720-05-8
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$5.00/1g
40808-21-7
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$65.00/100mg
38401-68-2
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40808-21-7
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16939-04-1
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$81.00/250mg
40808-21-7
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$65.00/100mg
38425-26-2
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$25.00/250mg
40808-21-7
12 suppliers
$65.00/100mg