(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol synthesis
- Product Name:(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol
- CAS Number:41790-30-1
- Molecular formula:C11H14O
- Molecular Weight:162.23
4242-18-6
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$6.00/100mg
41790-30-1
52 suppliers
$132.00/250mg
Yield:41790-30-1 100%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20; for 16 h;
Steps:
1 synthesis of (5,6,7,8-tetrahydronaphthalene 1-yl)methanol
5,6,7,8-tetrahydronaphthalene 1-carboxylic acid (2.0 g, 11mmol) was dissolved in the tetrahydrofuran (following, THF) (30 mL), borane.THF (23 mL, a 0.98M THF solution, 23mmol) were added at 0 degree C, and it agitated at the room temperature for 16 hours. Water was added to the reaction solution at 0 degree C, and ethyl acetate extracted. The saturated sodium chloride solution washed the organic layer, and it condensed after drying with anhydrous sodium sulfate, and obtained the rough product. silica gel column chromatography (n-hexane -> n-hexane/ethyl acetate =3/1) refined the obtained rough product, and it obtained the title compound (1.9 g and colourless oil, quantitive)
References:
JP2016/222570,2016,A Location in patent:Paragraph 0034
41828-13-1
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41790-30-1
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$132.00/250mg
74145-11-2
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41790-30-1
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66193-59-7
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41790-30-1
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66-77-3
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41790-30-1
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$132.00/250mg