5,6,7,8-TETRAHYDRONAPHTHALENE-2-YL-ACETAMIDE synthesis

13synthesis methods

Product Name:5,6,7,8-TETRAHYDRONAPHTHALENE-2-YL-ACETAMIDE
CAS Number:50878-03-0
Molecular formula:C12H15NO
Molecular Weight:189.25

581-97-5 Synthesis

581-97-5
41 suppliers
$172.00/250mg

Carbamimidic chloride, N,N'-dicyclohexyl- (9CI)

114316-64-2
0 suppliers
inquiry

Yield:114316-64-2 92%

Reaction Conditions:

with hydrogen in ethanol at 25 - 30;

Steps:

5 Example 5

250 ml single-neck reaction flask, 8.5 g (0.046 mol) of N-acetyl-2-naphthylamine was added and dissolved with 140 ml of ethanol.The resulting solution were added 1.2g additives diatomaceous earth, particle size 21.8μm; 1g catalyst Ni, the resulting system atmospheric pressure into the hydrogen andThe reaction is stirred at room temperature (25 ° C-30 ° C). When the system is no longer hydrogen absorption, the reaction is complete, stand and filter, the filter cake with 20mlEthanol 2 times, the filtrate was concentrated under reduced pressure at 60 ° C to remove the solvent 2-acetamido-5,6,7,8-tetrahydronaphthalene 7.9g, yield 92%Purity 98.2% (HPLC).

References:

CN104355954,2017,B Location in patent:Paragraph 0031; 0032

2217-43-8 Synthesis