5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE& synthesis
- Product Name:5-AMINO-1-(4-METHOXYPHENYL)-1H-PYRAZOLE&
- CAS Number:14678-95-6
- Molecular formula:C11H11N3O3
- Molecular Weight:233.22
15001-13-5
21 suppliers
$33.39/250mg
14678-95-6
54 suppliers
$24.00/250mg
Yield:14678-95-6 65%
Reaction Conditions:
with sodium hydroxide in ethanolHeating;
Steps:
General procedure for synthesis ofsubstituted 5-amino-1H-pyrazole-4-carboxylic acid (3)
General procedure: 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid (3a)Ethanolic solution of NaOH (3 equivalents) was added to ethanolic solution of ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (1 equivalent) (2a). The reaction mixture was refluxed at 70C for 5-6 hours. Aqueous work up was done by adding reaction mixture in ice cold water and pH was made acidic. The white precipitate formed was filtered off and dried. Yield: 78%; Melting point: 191°C; LC-ESI-MS (m/z): 204.2 (M+1)
References:
Sagar, Sneha R.;Agarwal, Jessica K.;Pandya, Dhaivat H.;Dash, Ranjeet Prasad;Nivsarkar, Manish;Vasu, Kamala K. [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 20,p. 4428 - 4433] Location in patent:supporting information
3471-32-7
30 suppliers
inquiry
14678-95-6
54 suppliers
$24.00/250mg