5-Benzyloxy-2-methyl-2H-pyrazole-3-carboxylic acid synthesis
- Product Name:5-Benzyloxy-2-methyl-2H-pyrazole-3-carboxylic acid
- CAS Number:1313389-24-0
- Molecular formula:C12H12N2O3
- Molecular Weight:232.24
628329-62-4
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1313389-24-0
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Yield:1313389-24-0 98%
Reaction Conditions:
Stage #1: methyl 3-(benzyloxy)-1-methyl-1H-pyrazole-5-carboxylatewith potassium hydroxide in 1,4-dioxane;water at 20; for 6 h;
Stage #2: with hydrogenchloride in water; pH=4 - 5;
References:
Baraldi, Pier Giovanni;Baraldi, Stefania;Saponaro, Giulia;Preti, Delia;Romagnoli, Romeo;Piccagli, Laura;Cavalli, Andrea;Recanatini, Maurizio;Moorman, Allan R.;Zaid, Abdel Naser;Varani, Katia;Borea, Pier Andrea;Tabrizi, Mojgan Aghazadeh [Journal of Medicinal Chemistry,2012,vol. 55,# 2,p. 797 - 811] Location in patent:supporting information; experimental part
100-39-0
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52867-42-2
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