5-BroMo-1-ethylpyridin-2(1h)-one synthesis
- Product Name:5-BroMo-1-ethylpyridin-2(1h)-one
- CAS Number:63785-87-5
- Molecular formula:C7H8BrNO
- Molecular Weight:202.05
74-96-4
452 suppliers
$9.00/5g
13466-38-1
403 suppliers
$6.00/5g
63785-87-5
46 suppliers
$15.00/250mg
Yield:63785-87-5 74%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 18 - 25;
Steps:
23.D [257j Step D. Preparation of 5-bromo-1-ethylpyridin-2(1H)-one.
To a solution of 5-bromopyridin-2(1H)-one (1.0 g, 6.0 mmol) and K2C03 (2.0 g, 15 mmol) in DMF (10 mL) was added ethyl bromide (0.7 g, 7.5 mmol). The resulting mixture wasstirred overnight at room temperature. Afterward, the mixture was diluted with ethyl acetate (50 mL), washed with H20 (50 mL) and brine (100 mL), dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluting with petroleum ether /ethyl acetate (20/1) to afford 0.9 g (74%) of the title product as a brown oil. LC/MS: mlz 202 [M+H]
References:
WO2016/46260,2016,A1 Location in patent:Paragraph 257
13466-38-1
403 suppliers
$6.00/5g
75-03-6
363 suppliers
$11.00/5g
63785-87-5
46 suppliers
$15.00/250mg
13466-38-1
403 suppliers
$6.00/5g
75-03-6
363 suppliers
$11.00/5g
63785-87-5
46 suppliers
$15.00/250mg
81590-30-9
22 suppliers
inquiry
75-03-6
363 suppliers
$11.00/5g
63785-87-5
46 suppliers
$15.00/250mg
