5-BroMo-1-ethylpyridin-2(1h)-one synthesis

8synthesis methods

Product Name:5-BroMo-1-ethylpyridin-2(1h)-one
CAS Number:63785-87-5
Molecular formula:C7H8BrNO
Molecular Weight:202.05

74-96-4 Synthesis

74-96-4
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$9.00/5g

13466-38-1 Synthesis

13466-38-1
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$6.00/5g

63785-87-5
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$15.00/250mg

Yield:63785-87-5 74%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 18 - 25;

Steps:

23.D [257j Step D. Preparation of 5-bromo-1-ethylpyridin-2(1H)-one.

To a solution of 5-bromopyridin-2(1H)-one (1.0 g, 6.0 mmol) and K2C03 (2.0 g, 15 mmol) in DMF (10 mL) was added ethyl bromide (0.7 g, 7.5 mmol). The resulting mixture wasstirred overnight at room temperature. Afterward, the mixture was diluted with ethyl acetate (50 mL), washed with H20 (50 mL) and brine (100 mL), dried over Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluting with petroleum ether /ethyl acetate (20/1) to afford 0.9 g (74%) of the title product as a brown oil. LC/MS: mlz 202 [M+H]

References:

WO2016/46260,2016,A1 Location in patent:Paragraph 257

13466-38-1 Synthesis

13466-38-1
387 suppliers
$6.00/5g