5-BROMO-1-METHYL-2(1H)-PYRIDINONE synthesis
- Product Name:5-BROMO-1-METHYL-2(1H)-PYRIDINONE
- CAS Number:81971-39-3
- Molecular formula:C6H6BrNO
- Molecular Weight:188.02
13466-38-1
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81971-39-3
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Yield:81971-39-3 96.78%
Reaction Conditions:
Stage #1: 5-bromopyridin-2(1H)-onewith sodium hydride in tetrahydrofuran at 0; for 1 h;
Stage #2: methyl iodide in tetrahydrofuran; for 3 h;
Steps:
30.1
To a suspension of NaH (4.8 g, 0.2 mol) in THF (10 mL) was added a solution of 5-bromopyridin-2(1H)-one (8.6 g, 0.05 mol) in THF (120 mL) at 0° C. The resulting mixture was stirred for 1 h and CH3I (35.5 g, 0.25 mol) was added. The mixture was stirred for 3 h. The reaction was quenched with aqueous NH4Cl solution. The organic phase was concentrated to give the crude product, which was purified by column chromatography to give 5-bromo-1-methylpyridin-2(1H)-one (8.9 g, 96.78%). 1H NMR (CDCl3): δ=3.5 (S, 3H), 6.52 (m, 1H), 7.32 (m, 1H), 7.45 (m, 1H).
References:
US2010/331320,2010,A1 Location in patent:Page/Page column 56
13466-38-1
403 suppliers
$6.00/5g
74-88-4
351 suppliers
$15.00/10g
81971-39-3
117 suppliers
$45.00/100mg
694-85-9
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81971-39-3
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$45.00/100mg
13472-85-0
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74-88-4
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81971-39-3
117 suppliers
$45.00/100mg
13472-92-9
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74-88-4
351 suppliers
$15.00/10g
81971-39-3
117 suppliers
$45.00/100mg