5-Bromo-1H-indol-3-amine synthesis
- Product Name:5-Bromo-1H-indol-3-amine
- CAS Number:69343-99-3
- Molecular formula:C8H7BrN2
- Molecular Weight:211.06
1260655-97-7
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Yield:69343-99-3 92%
Reaction Conditions:
with glacial acetic acid;stannous chloride at 85; for 2 h;
Steps:
Step 2
To a stirred solution of 5-bromo-3-nitro-1H-indole (100 mg, 0.414 mmol) in AcOH (2.0 mL) was added SnCl2(78.7 mg, 0.415 mmol) at 25 . The resulting mixture was warmed to 85 and stirred at that temperature for 2 h. The mixture was cooled to 25 and concentrated under reduced pressure to give 5-bromo-1H-indol-3-amine (80.0 mg, 92%yield) as a yellow solid which was used directly in the next step without further purification. LC-MS: m/z [M+H]+211.1.
References:
WO2022/105930,2022,A1 Location in patent:Page/Page column 62
76983-63-6
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10075-50-0
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10406-06-1
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$6.00/100mg
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