5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE synthesis
- Product Name:5-BROMO-2,3-DIHYDRO-ISOINDOL-1-ONE
- CAS Number:552330-86-6
- Molecular formula:C8H6BrNO
- Molecular Weight:212.04
78471-43-9
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552330-86-6
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Yield:552330-86-6 90%
Reaction Conditions:
with ammonia in methanol;water; for 18 h;
Steps:
25
[0189] 4-Bromo-2-bromomethyl-benzoic acid methyl ester (3.70g) was suspended in 2M NH3 in MeOH (36mL) and concentrated ammonium hydroxide (12mL) for eighteen hours. The solid product was filtered to provide the title compound as a colourless solid (2.3 Og, 90%). .H NMR (300MHz, CDCI3): 6 7.68 (m, 3H), 4.44 (s, 2H).
References:
WO2006/20879,2006,A1 Location in patent:Page/Page column 66-67
68837-59-2
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552330-86-6
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201230-82-2
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10269-01-9
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552330-86-6
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99548-55-7
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552330-86-6
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21900-45-8
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552330-86-6
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