5-bromo-3-fluoro-2-nitropyridine synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: N-Bromosuccinimide / acetonitrile / 1 h / 0 - 20 °C
2: sulfuric acid; dihydrogen peroxide / 0 - 20 °C

References:

SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.;CHONGQING FOCHON PHARMACEUTICAL CO., LTD.;ZHAO, Xingdong;LI, Tongshuang;ZHOU, Zuwen;WANG, Xianlong;CHEN, Ling;RONG, Yue;LIU, Qihong;CHEN, Zhifang;ZHANG, Huajie;TAN, Rui;TAN, Haohan;LI, Zhifu;ZHANG, Weipeng;JIANG, Lihua;LIU, Yanxin;LINGHU, Li;LIN, Min;SUN, Jing;WANG, Weibo WO2017/133701, 2017, A1

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