5-Bromo-3-nitro-benzene-1,2-diamine synthesis
- Product Name:5-Bromo-3-nitro-benzene-1,2-diamine
- CAS Number:84752-20-5
- Molecular formula:C6H6BrN3O2
- Molecular Weight:232.03
62554-90-9
45 suppliers
inquiry
84752-20-5
49 suppliers
$35.00/100mg
Yield:84752-20-5 51%
Reaction Conditions:
with diammonium sulfide in ethanol at 90; for 2 h;
Steps:
31.1 Step 1: 5-bromo-3-nitrobenzene-l,2-diamine
A mixture of 4-bromo-2,6-dinitroaniline (5.5 g, 21.2 mmol) and (NH4)2S (10.5 mL, 21.2 mmol) in ethanol (150 mL) was heated at 90 °C for 1 hr. TLC showed incomplete consumption of starting material. Additional (NH 2S (10.5 mL, 21.2 mmol) was added, and the reaction was stirred at 90 °C for 1 hr more. The mixture was concentrated and purified on silica gel (PE/DCM = 1 : 1) to give the title compound (2.5 g, 51%) as a red solid. LCMS: 230, 232 (M-H ).
References:
WO2016/168682,2016,A2 Location in patent:Paragraph 0288
606-22-4
16 suppliers
$47.29/5g
84752-20-5
49 suppliers
$35.00/100mg