5-bromo-4-chloro-thiazol-2-ylamine synthesis

Yield:1174132-80-9 82%

Reaction Conditions:

Stage #1: 4-chloro-thiazol-2-ylaminewith bromine;acetic acid at 0; for 1 h;
Stage #2: with sodium carbonate in dichloromethane;water;isopropyl alcohol;

References:

Gibson, Christoph;Schnatbaum, Karsten;Pfeifer, Jochen R.;Locardi, Elsa;Paschke, Matthias;Reimer, Ulf;Richter, Uwe;Scharn, Dirk;Faussner, Alexander;Tradler, Thomas [Journal of Medicinal Chemistry,2009,vol. 52,# 14,p. 4370 - 4379] Location in patent:supporting information; experimental part