5-bromo-4-chloropyrimidin-2-amine synthesis

Yield: 86%

Reaction Conditions:

with bromine;acetic acid at 20; for 2 h;

References:

Leahy, James W.;Buhr, Chris A.;Johnson, Henry W. B.;Kim, Byung Gyu;Baik, Taegon;Cannoy, Jonah;Forsyth, Timothy P.;Jeong, Joon Won;Lee, Matthew S.;Ma, Sunghoon;Noson, Kevin;Wang, Longcheng;Williams, Matthew;Nuss, John M.;Brooks, Eric;Foster, Paul;Goon, Leanne;Heald, Nathan;Holst, Charles;Jaeger, Christopher;Lam, Scott;Lougheed, Julie;Nguyen, Lam;Plonowski, Arthur;Song, Joanne;Stout, Thomas;Wu, Xiang;Yakes, Michael F.;Yu, Peiwen;Zhang, Wentao;Lamb, Peter;Raeber, Olivia [Journal of Medicinal Chemistry,2012,vol. 55,# 11,p. 5467 - 5482] Location in patent:experimental part