5-bromo-6-iodopyrimidin-4-amine synthesis

Yield:926009-55-4 61%

Reaction Conditions:

with tribromide;sodium hydrogencarbonate in methanol;water;

References:

Matulenko, Mark A.;Paight, Ernest S.;Frey, Robin R.;Gomtsyan, Arthur;DiDomenico Jr., Stanley;Jiang, Meiqun;Lee, Chih-Hung;Stewart, Andrew O.;Yu, Haixia;Kohlhaas, Kathy L.;Alexander, Karen M.;McGaraughty, Steve;Mikusa, Joseph;Marsh, Kennan C.;Muchmore, Steven W.;Jakob, Clarissa L.;Kowaluk, Elizabeth A.;Jarvis, Michael F.;Bhagwat, Shripad S. [Bioorganic and Medicinal Chemistry,2007,vol. 15,# 4,p. 1586 - 1605]