5-(bromomethyl)-2,2-dimethyl-1,3-dioxane synthesis
- Product Name:5-(bromomethyl)-2,2-dimethyl-1,3-dioxane
- CAS Number:111934-94-2
- Molecular formula:C7H13BrO2
- Molecular Weight:209.08
4728-12-5
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111934-94-2
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Yield:111934-94-2 100%
Reaction Conditions:
with 1H-imidazole;carbon tetrabromide;triphenylphosphine in dichloromethane at 20; for 4 h;Cooling with ice;
Steps:
B4.B' Synthesis of 2,2-dimethyl-5-bromomethyl-1,3-dioxane (5b)
j0363] 2,2-Dimethyl-5-(hydroxymethyl)-1 ,3-dioxane (3a) (1.00 g) was dissolved in 22.8 mE of dichloromethane (MDC), and 700.0 mg of imidazole and 2.72 g of carbon tetrabromide were added thereto. After ice-cooling, 2.15 g of triphenylphosphine was thrther added, and the mixture was stirred at room temperature for 4 hours. Dichloromethane was distilled off under reduced pressure, and the resulting product was purified with silica gel chromatography (n-hexane:ethyl acetate=5: 1) to quantitatively obtain 1.60 g of 2,2-dimethyl-5-bromomethyl- 1 ,3-dioxane (Sb).
References:
US2017/233421,2017,A1 Location in patent:Paragraph 0362; 0363
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51335-75-2
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82962-54-7
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