5-(Bromomethyl)-2-methylthiazole synthesis
- Product Name:5-(Bromomethyl)-2-methylthiazole
- CAS Number:838892-95-8
- Molecular formula:C5H6BrNS
- Molecular Weight:192.08
56012-38-5
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$45.00/5mg
838892-95-8
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$45.00/10mg
Yield:838892-95-8 3.3g
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 2 h;
Steps:
2 Step 2:
Step 2:
Synthesis of 2-methyl-5-bromomethylthiazole
At room temperature, 2-methyl-5-hydroxymethylthiazole (12g) was dissolved in methylene chloride (500mL), and the resulting solution was cooled to 0-5°C in an ice-water bath.
To the cooled mixture were added successively and in batches triphenylphosphine (52g, 200mmol) and carbon tetrabromide (66g, 200mmol).
After the completion of the addition, the reaction mixture was naturally warmed to room temperature, stirred for 2 hours at room temperature, concentrated, and purified by a silica gel column chromatography (petroleum ether:ethyl acetate=2:1) to produce a yellow solid (3.3g, the total yield for two steps: 15%).
References:
EP3181554,2017,A1 Location in patent:Paragraph 0092
4175-66-0
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838892-95-8
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$45.00/10mg
79836-78-5
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$13.43/250mgs:
838892-95-8
47 suppliers
$45.00/10mg