5-BUTYL-THIOPHENE-2-CARBALDEHYDE synthesis
- Product Name:5-BUTYL-THIOPHENE-2-CARBALDEHYDE
- CAS Number:98954-25-7
- Molecular formula:C9H12OS
- Molecular Weight:168.26
1455-20-5
102 suppliers
$15.00/5g
93-61-8
299 suppliers
$10.00/5G
98954-25-7
32 suppliers
$84.00/250mg
Yield:98954-25-7 99%
Reaction Conditions:
with trichlorophosphate
Steps:
1 EXAMPLE 1
EXAMPLE 1 This Example illustrates the preparation of 4-[2-(5-n-butylthiophen-2-yl)-trans-cyclopropylmethyl]-2,6-cis-dimethylmorpholine (Compound No. 8 in Table I). Phosphorus oxychloride (12.02 g, 0.078 mol) was added dropwise to N-methylformanilide (10.62 g, 0.079 mol) and a yellow solid was produced. This was cooled to 0° C. for 1/2 hour, then 2-n-butylthiophene (10 g, 0.071 mol) was added dropwise and the mixture stirred at room temperature for 3 hours. The mixture was poured into ice/water, neutralised with sodium carbonate and extracted into diethyl ether. The ethereal extracts were washed with water, dried over anhydrous sodium sulphate and the solvent removed to give a brown oil. Purification by column chromatography (silica eluted with petroleum ether/ethyl acetate 9:1) gave 5-n-butyl-2-thiophenecarboxaldehyde (11.8 g, 99%).
References:
US4743602,1988,A
5333-83-5
74 suppliers
$18.00/5g
98954-25-7
32 suppliers
$84.00/250mg