5-Chloro-2-cyclopropyl-6-methyl-pyrimidin-4-ol synthesis
1synthesis methods
- Product Name:5-Chloro-2-cyclopropyl-6-methyl-pyrimidin-4-ol
- CAS Number:287927-87-1
- Molecular formula:C8H9ClN2O
- Molecular Weight:184.62
Yield:287927-87-1 62.3%
Reaction Conditions:
with potassium tert-butylate in methanol at 0; for 4.5 h;Reflux;
References:
Lan, Yu;Chen, Yin;Cao, Xudong;Zhang, Juecheng;Wang, Jie;Xu, Xiangqing;Qiu, Yinli;Zhang, Tan;Liu, Xin;Liu, Bi-Feng;Zhang, Guisen [Journal of Medicinal Chemistry,2014,vol. 57,# 24,p. 10404 - 10423]