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126215-85-8

5-Chloro-2-(pent-4-yn-1-yl)pyriMidine synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: hydrogenchloride / 32 h / 0 °C
2: ammonia / methanol / 60 h
3: sodium methylate / methanol / 2 h / Reflux

References:

Martin, Rainer E.;Morawitz, Falk;Kuratli, Christoph;Alker, Andre M.;Alanine, Alexander I. [European Journal of Organic Chemistry,2012,# 1,p. 47 - 52]