5-CYANO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE synthesis
- Product Name:5-CYANO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE
- CAS Number:683274-61-5
- Molecular formula:C15H20N4O2
- Molecular Weight:288.34
33252-28-7
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Yield:683274-61-5 73%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl acetamide at 20 - 60; for 6 h;Inert atmosphere;
Steps:
11.1 Step-1
To a stirred solution of 6-chloropyridine-3-carbonitrile (2 g, 14.43 mmol) in DMA (20 mL),K2C03 (3.4 g, 24.63 mmol), N-Boc-piperazine (2.7 g, 14.50 mmol) were added at RT underargon atmosphere and stirred for 3 h. The reaction mixture was heated at 60 °C for 3 h (TLCindicated complete consumption of starting material) and poured into ice-water (100 mL)during which solid precipitated out which was filtered, washed with Et20 (3 x 10 mL),pentane (3 x 10 mL) and dried to afford tert-butyl4-(5-cyano-2-pyridyl)piperazine-1-carboxylate (3 g, 73%) which was used without purification.LCMS: mlz: 289.3 [M+Ht.
References:
WO2018/125961,2018,A1 Location in patent:Page/Page column 47
557-21-1
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