5-cyclopropylisoxazol-3-amine synthesis
- Product Name:5-cyclopropylisoxazol-3-amine
- CAS Number:21080-85-3
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
118431-88-2
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21080-85-3
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Yield:21080-85-3 65%
Reaction Conditions:
Stage #1: β-cyclopropyl-β-oxopropionitrilewith hydroxylammonium sulphate;sodium hydroxide in lithium hydroxide monohydrate at 45; pH=7 - 8; for 72 h;Inert atmosphere;
Stage #2: with hydrogenchloride in lithium hydroxide monohydrate at 50; for 2.5 h;Inert atmosphere;
References:
Johnson, Leland;Powers, James;Ma, Fupeng;Jendza, Keith;Wang, Bing;Meredith, Erik;Mainolfi, Nello [Synthesis,2013,vol. 45,# 2,p. 171 - 173]