5-fluoro-1H-Isoindole-1,3(2H)-dione synthesis
- Product Name:5-fluoro-1H-Isoindole-1,3(2H)-dione
- CAS Number:94514-21-3
- Molecular formula:C8H4FNO2
- Molecular Weight:165.12
319-03-9
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Yield:94514-21-3 100%
Reaction Conditions:
with urea in toluene; for 16 h;Reflux;
Steps:
61; 62
To 4-fluorophthalic anhydride (5.0 g, 30.10 mmol) in toluene (15 mL) is added urea (2.1 g). The reaction mixture is stirred at refluxed for 16 h. The reaction mixture is allowed to cool to room temperature, concentrated under reduced pressure and triturated with H20 (250 mL) to afford 5-fluoro-isoindole-l,3-dione (5.0 g, 100%) as a white solid.
References:
WO2011/68821,2011,A1 Location in patent:Page/Page column 145
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