5-Fluoro-2-Methyl-3-nitrobenzoic acid synthesis
- Product Name:5-Fluoro-2-Methyl-3-nitrobenzoic acid
- CAS Number:850462-64-5
- Molecular formula:C8H6FNO4
- Molecular Weight:199.14
33184-16-6
315 suppliers
$6.00/1g
850462-64-5
93 suppliers
$11.00/250mg
Yield: 70.5%
Reaction Conditions:
with sulfuric acid;nitric acid in dichloromethane at 30 - 40; for 3 h;Temperature;Reagent/catalyst;
Steps:
6 Preparation of 2-methyl-3-nitro-5-fluorobenzoic acid
30 g (0.195 mol) of 2-methyl-5-fluorobenzoic acid was added to a mixed solution of 30 ml of concentrated sulfuric acid and 150 ml of dichloromethane, and the mixture was heated to 30 ° C to 40 ° C with stirring.24.5 g (0.39 mol) of fuming nitric acid was added dropwise, and the temperature was controlled at 30-40 °C.After the completion of the dropwise addition, the reaction was carried out for 3 hours, the raw materials basically disappeared, the reaction was stopped, and the reaction solution was taken., pour into ice water. Filter, filter cake rinsed with water and drained. A wet product was obtained, dried at 50 ° C to give 30 g, HPLC 94%. The pure yield was 70.5%.
References:
Zhejiang Tianyu Pharmaceutical Co., Ltd.;Shanghai Xinbu Pharmaceutical Technology Co., Ltd.;Wang Xueyue;Li Gongyong;Chen Kexi CN108929217, 2018, A Location in patent:Paragraph 0080; 0084; 0086; 0087; 0088
452-73-3
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$6.00/25g
850462-64-5
93 suppliers
$11.00/250mg
1422-53-3
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$5.00/5g
850462-64-5
93 suppliers
$11.00/250mg
13194-67-7
158 suppliers
$10.00/5g
850462-64-5
93 suppliers
$11.00/250mg