5-HEPTYL-[1,3,4]THIADIAZOL-2-YLAMINE synthesis
- Product Name:5-HEPTYL-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS Number:75122-52-0
- Molecular formula:C9H17N3S
- Molecular Weight:199.32
124-07-2
684 suppliers
$6.00/25g
79-19-6
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$14.00/1g
75122-52-0
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$345.00/250mg
Yield:75122-52-0 95.8%
Reaction Conditions:
with SO42-/TiO2 at 20; for 0.166667 h;Microwave irradiation;
Steps:
3
General procedure: The first part, the general procedure of 2-aminomethyl-5-alkyl-1,3,4-oxadiazole compounds of embodiment: at room temperature 0.6mol long chain carboxylic acids, and 0.5mol thiosemicarbazide of SO42-/ TiO2Solid super acid placed in a laboratory ball mill grinding of 200 to 300 mesh.The ground mixture was added 250mL good reaction flask under 500W microwave power irradiation assisted heating 5 ~ 10min, was added 200mL × 2 methanol reaction mixture was extracted, filtered, the filtrate by rotary evaporation, the resulting solid was washed with concentrated aqueous ammonia alkali washing, filtration to give long chain thiadiazole compound was recrystallized from ethanol and water to give a pale yellow solid 2-amino-5-alkyl-1,3,4-thiadiazole compound. Long chain carboxylic acid is n-octanoic acid, according to reaction step 2-amino-1,3,4-thiadiazole-alkyl compound prepared in the general procedure, which of SO42-/ of TiO2Solid superacid amount of 90g, microwave assisted heating 10min, was prepared to give 2-amino-5-n-heptyl-1,3,4-thiadiazole compound, a yield of 95.8%.Mp 185.4 ~ 186.1°C.
References:
CN105399704,2016,A Location in patent:Paragraph 0033; 0038; 0039
79-19-6
487 suppliers
$14.00/1g
111-64-8
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$15.00/25mL
75122-52-0
15 suppliers
$345.00/250mg