5-Hydroxy-7-acetoxy-8-methoxyflavone synthesis
- Product Name:5-Hydroxy-7-acetoxy-8-methoxyflavone
- CAS Number:95480-80-1
- Molecular formula:C18H14O6
- Molecular Weight:326.3002
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Yield:95480-80-1 81%
Reaction Conditions:
at 70; for 3 h;Inert atmosphere;
Steps:
5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate (7-acetyl wogonin).
Amixture of wogonin (568 mg, 2 mmol) and sodium acetate (213 mg, 2.6 mmol, 1.3equiv) were loaded into a flask (25 mL) under atmosphere of argon. Aceticanhydride (10 mL) was then added. The mixture was heated at 70 °C for 3 h andthen the reaction mixture was concentrated under reduced pressure. 10 mL ofEtOAc and 10 mL of water were added. The organic layer was separated and theaqueous layer was extracted with EtOAc (3 × 10 mL), and the combined organiclayers were dried over anhydrous Na2SO4, and filtration and removal of solventunder vacuum. The crude material was purified by column chromatography (DCM: MeOH 100:1) to afford 7-acetyl wogonin as yellowish solids (528 mg, 81%).
References:
Jiang, Xueyang;Zhou, Junting;Zhou, Yue;Sun, Haopeng;Xu, Jian;Feng, Feng;Qu, Wei [Molecules,2018,vol. 23,# 7,art. no. 1715] Location in patent:supporting information
632-85-9
324 suppliers
$29.00/10mg
108-24-7
0 suppliers
$14.00/250ML
95480-80-1
49 suppliers
inquiry