(5-METHOXY-2-NITRO-PHENYL)-ACETIC ACID synthesis
- Product Name:(5-METHOXY-2-NITRO-PHENYL)-ACETIC ACID
- CAS Number:20876-29-3
- Molecular formula:C9H9NO5
- Molecular Weight:211.17
89302-15-8
20876-29-3
General procedure for the synthesis of 2-nitro-5-methoxyphenylacetic acid from 5-methoxy-2-nitrophenylacetonitrile: 1 equivalent of 5-methoxy-2-nitrophenylacetonitrile was dissolved in a mixture of acetic acid (AcOH) and concentrated hydrochloric acid (HCl) (1:5, v/v), and the reaction mixture was heated for 4 hr under reflux conditions. Upon completion of the reaction, the target product 2-nitro-5-methoxyphenylacetic acid was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate (Na2SO4), followed by removal of solvent by rotary evaporator to give the product.
89302-15-8
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20876-29-3
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Yield:20876-29-3 87%
Reaction Conditions:
with hydrogenchloride;acetic acid for 4 h;Reflux;
Steps:
Typical procedure for the hydrolysis of the nitrileunder acid conditions:
General procedure: 1 equivalent of nitrile was dissolved in a mixture of AcOH/HCl (1:5) andrefluxed for 4 h. The product was extracted with ethyl acetate, dried over Na2SO4and evaporated.
References:
Schlosser, Joachim;Johannes, Eugen;Zindler, Melanie;Lemmerhirt, Jan;Sommer, Benjamin;Schütt, Martin;Peifer, Christian [Tetrahedron Letters,2015,vol. 56,# 1,p. 89 - 94] Location in patent:supporting information
117559-88-3
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20876-29-3
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5367-32-8
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$10.00/5g
95-92-1
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$5.00/5G
20876-29-3
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$39.00/100mg
2581-34-2
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20876-29-3
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$39.00/100mg
100-17-4
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$23.00/25g
20876-29-3
59 suppliers
$39.00/100mg